Bladder cancer is considered as the most common types of cancer and is likely to affect men more than women. Recently, the Food and Drug Administration (FDA) approved the use of Nivolumab for the treatment of patients who have bladder cancer. The combination of Nivolumab and Ipilimumab was evaluated in an appearance I clinical trial. In a recent research, 41 patients were treated with a Nivolumab 1mg/kg plus Ipilimumab 3mg/kg dose, out of which doctors got few positive and good results.
Nivolumab is used for the treatment of metastatic bladder cancer among patients whose disease has gotten worse. The FDA approval given to use Nivolumab for the treatment of metastatic bladder cancer was on the basis of the results of Nivolumab clinical trial, which gave positive results. Nivolumab clinical trial was done on 270 patients who were suffering from advanced or metastatic bladder cancer that had worsened over time. 19% of these patients who received Nivolumab had tumor shrinkage for a median of 10.3 months. Out of 53 patients who had tumor shrinkage, 7 patients had complete tumor shrinkage and 46 patients who had partial tumor shrinkage.
Nivolumab functions by releasing a protein called Pd-1 on cancer-fighting immune cells called T cells. Once Nivolumab releases PD-1 protein, T cells can destroy the cancer cells.
Implications of Nivolumab
As there were few options available for treatment of metastatic bladder cancer, doctors started using Nivolumab soon after Nivolumab clinical trial results were approved by FDA. In contrast to typical short-lived responses with cancer therapy in solid metastatic tumors, many responses induced by Nivolumab appear persistent. These persistent results only increased the use of Nivolumab for people who have metastatic bladder cancer.
Note of caution
If a patient is or was on some prescribed drug or has used some herbal products, then he/she must tell this to the doctor before using Nivolumab. Although Nivolumab clinical trial results are positive and FDA-approved, there are many drugs and over-the-counter medicines, which can interact with Nivolumab and deteriorate the situation.
Bruises are inevitable; they are part and parcel of our day to day life. We are bound to face them and incur some injuries in the process. The magnitude of the injury depends on the intensity of the fall. Bruises usually heal on them, but that takes a substantial amount of time, and the bruise also gives you different levels of pain in the process. You can heal your bruise quickly with the help of some home remedies as well as some medication or ointment available at the drug stores.
Let us look at some of the home remedies to heal bruise quickly:
In case the iPhone 7 fever has got to you, and you wish to be the proud owner of an iPhone 7, here are some amazing iPhone 7 deals provided by none other than USA’s best cell phone service providers.
Verizon
Verizon, number 1 network in the USA, offers you not one, but two lucrative deals to get iPhone 7. These are:-
For Verizon customers: First deal offers to provide iPhone 7 128GB at the same price of iPhone 7 32GB, i.e. at $749. If you want to upgrade your iPhone 7 32GB to 128GB or 256GB variant, Verizon will offer you $100 discount. In order to avail this offer, you also have to sign up for a new line of service with the carrier’s Unlimited Plan. All iPhone 7 Plus users, including iPhone 7 Plus 128GB variant can also avail this offer.
For non-Verizon customers: This deal involves exchanging your old phone and also porting your number from a rival carrier. So, when you opt for a new device payment plan with Verizon, you will get a $650 Visa prepaid card.
AT&T
AT&T allows you to get your second iPhone 7 for free through its BOGO iPhone offer. To avail this offer, first, you need to sign up for an AT&T Next Plan. Along with that, you need to open two lines – plan for the first line should be $50 or more, and the second plan should be a minimum of $20. It is also mandatory to subscribe to DirecTv that will cost $29.99. This offer applies to all iPhone 7 Plus variants, including iPhone 7 Plus 128GB.
T-Mobile
T-Mobile provides the best deals on iPhone 7 models with an attractive free upgrade option on storage. Thus, it is offering iPhone 7 256GB variant at the price of iPhone 7 128GB variant. So, it is for you to decide by paying $749, you want to purchase iPhone 7 128GB from outside dealer or iPhone 7 256GB from T-mobile.
In an exclusive BOGO iPhone offer, you will receive a $400 prepaid card in case you purchase a brand new iPhone from a carrier.
Sprint
Sprint offers a bumper bonanza in which you will get a second iPhone 7 free for purchasing one iPhone 7. To avail this offer, you need to pay for one iPhone 7 32GB in an EMI of $27.08 per month, over a period of 18 months. In this way, you will get your second iPhone 7 32GB free of cost as it will be paid by Sprint. But, you need to make payment for two service lines.
Compare the deals and go for the one which suits you the best.
PlayStation, also known as Sony game consoles which are launched by Sony, is a popular gaming brand. It comprises four home game consoles, a media focus, an online administration, two handhelds along with a telephone, and various magazines. These gaming consoles, which are also releasing PlayStation 4 limited edition consoles, are manufactured by Sony Interactive Entertainment that is headquartered in Japan.
The PlayStation and the PlayStation 4 limited edition range have undergone various modifications since its inception and likewise, modified versions have been launched since then. Various ranges of consoles and other hardware devices launched in the past years can be listed as follows.
Home Game Consoles
PlayStation 1 It is the first console of the PlayStation series that comprised of portable gaming systems.
PlayStation 2 It is the modified version and successor of the original PlayStation version. The slimmer model is eye-catching and has recorded an overwhelming sale figure from its launch.
PlayStation 3 This seventh generation gaming console was first launched in the North American continent in the year 2006. Disc player with Blue Ray feature along with the high-resolution feature was launched for the first time with this console.
PlayStation 4 PlayStation 4 Slim was launched in September 2016. It is a modification of the first PS4 equipment with a streamlined factor. The new packaging is smaller and conveys an adjusted body with a matte finish. The appearance is not only attractive but also provides a secure hold.
Sony PlayStation 4 Pro is has been recently launched and is a rationalized version with higher CPU versions and enhanced resolution capacity. Almost all the games are forward and backward compatible.
Sony PlayStation 4 Vita Slim
Sony launched the PlayStation Vita Slim in the US on May 6, 2015. The adaptation of the PlayStation handheld has been accessible in Japan since the finish of a year ago and in the UK from February 7, 2016. Presently it’s accessible for gamers stateside as well. Much has been made of the Sony PlayStation Vita Slim’s capacity that makes it a remote play gadget for the PlayStation 4. Effortlessly, you can play and be a part of the PlayStation Vita amusements, watch films, and play your heart out. Simultaneously, you can keep on playing PlayStation 4 diversions on its screen when the principle TV is turned off or being utilized by another person as well.
PlayStation’s Enhanced Look
The PlayStation 4 range has launched the new and stylish PlayStation4 Glacier White console that has includes the capacity of PlayStation 4 500GB along with a wireless controller. Apart from the above-mentioned popular versions, the latest PlayStation VR enables all the other versions of the PlayStation series to be played with it.
These and many other PlayStation 4 limited edition consoles have redefined the future of gaming.